Eosinophilic granulomatosis with polyangiitis (Churg-Strauss syndrome)

A 52-year-old man with a known diagnosis of eosinophilic granulomatosis with polyangiitis (EGPA) presents with worsening asthma symptoms, fever, and weight loss. His laboratory tests show persistent eosinophilia and elevated inflammatory markers. His current medications include inhaled corticosteroids and bronchodilators. On examination, he has bilateral wheezes and mild ankle edema.

What is the most appropriate next step in the management of this patient?

A 60-year-old woman with eosinophilic granulomatosis with polyangiitis (EGPA) presents with chest pain and palpitations. She has a history of asthma and peripheral neuropathy. On examination, her heart rate is 110 bpm, and blood pressure is 130/80 mmHg. An ECG shows sinus tachycardia with no ST-T wave changes. Blood tests reveal elevated troponin levels.

What is the most likely cardiac complication associated with EGPA in this patient?

A 40-year-old man with eosinophilic granulomatosis with polyangiitis (EGPA) is being followed up after starting treatment with oral corticosteroids. He reports improvement in his symptoms but is concerned about potential side effects of long-term steroid use. His current eosinophil count is within normal range, and his respiratory symptoms are well controlled.

What is the most appropriate strategy for monitoring and managing potential long-term complications of corticosteroid therapy in this patient?

A 45-year-old woman with a history of asthma presents with worsening shortness of breath, wheezing, and a new onset of peripheral neuropathy affecting her right hand. She also reports sinusitis and nasal polyps. On examination, there are bilateral wheezes on lung auscultation, and she has decreased sensation in her right hand. Laboratory tests reveal a white blood cell count of 15 x 10^9/L with an eosinophil count of 2 x 10^9/L (elevated).

What is the most appropriate initial test to support the diagnosis of eosinophilic granulomatosis with polyangiitis (EGPA)?